Drug interactions
Metolazone + Treprostinil
Severity: Minor
Metolazone and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator that lowers blood pressure, and metolazone also reduces blood pressure through diuresis. Used together they may cause additive hypotension, which is often seen in pulmonary hypertension patients on diuretics.
What this interaction means in plain words
Metolazone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from vasodilation and volume depletion.
What to do
Monitor blood pressure and volume status when starting or titrating either drug, and reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Treprostinil
Frequently asked questions
Can I take Metolazone with Treprostinil?
MediHelp rates the interaction as minor. Metolazone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a vasodilator that lowers blood pressure, and metolazone also reduces blood pressure through diuresis. Used together they may cause additive hypotension, which is often seen in pulmonary hypertension patients on diuretics.
How serious is the interaction between Metolazone and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or titrating either drug, and reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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