Drug interactions
Metolazone + Umeclidinium-vilanterol
Severity: Moderate
Metolazone and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone causes potassium and magnesium loss, and vilanterol may further lower serum potassium. The combination can result in hypokalemia and ECG changes, particularly with higher beta-agonist exposure.
What this interaction means in plain words
Metolazone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide-like renal potassium wasting and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium and correct deficits. Use extra vigilance in patients with heart disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Metolazone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone causes potassium and magnesium loss, and vilanterol may further lower serum potassium. The combination can result in hypokalemia and ECG changes, particularly with higher beta-agonist exposure.
How serious is the interaction between Metolazone and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits. Use extra vigilance in patients with heart disease or on other QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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