Drug interactions
Metoprolol + Mirabegron
Severity: Moderate
Metoprolol and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol is extensively cleared by CYP2D6, and mirabegron has been shown to increase its exposure. This may cause excessive bradycardia and hypotension.
What this interaction means in plain words
Metoprolol and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing the first-pass and systemic metabolism of metoprolol.
What to do
Monitor heart rate and blood pressure after starting mirabegron, and reduce the metoprolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Mirabegron?
MediHelp rates the interaction as moderate. Metoprolol and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol is extensively cleared by CYP2D6, and mirabegron has been shown to increase its exposure. This may cause excessive bradycardia and hypotension.
How serious is the interaction between Metoprolol and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting mirabegron, and reduce the metoprolol dose if bradycardia or hypotension occurs.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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