Drug interactions
Metoprolol + Tipranavir
Severity: Moderate
Metoprolol and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which inhibits CYP2D6 and can raise metoprolol exposure. This may cause bradycardia, hypotension and fatigue.
What this interaction means in plain words
Metoprolol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by the ritonavir-boosted regimen.
What to do
Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metoprolol with Tipranavir?
MediHelp rates the interaction as moderate. Metoprolol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is given with ritonavir, which inhibits CYP2D6 and can raise metoprolol exposure. This may cause bradycardia, hypotension and fatigue.
How serious is the interaction between Metoprolol and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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