Drug interactions
Mexiletine + Zileuton
Severity: Moderate
Mexiletine and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is metabolized in part by CYP1A2 and CYP2D6, and zileuton may raise its concentrations. This could increase gastrointestinal and neurologic adverse effects and proarrhythmic risk.
What this interaction means in plain words
Mexiletine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing mexiletine clearance.
What to do
Monitor for tremor, dizziness, nausea and arrhythmia and reduce the mexiletine dose if they occur. Check plasma levels when available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Mexiletine with Zileuton?
MediHelp rates the interaction as moderate. Mexiletine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mexiletine is metabolized in part by CYP1A2 and CYP2D6, and zileuton may raise its concentrations. This could increase gastrointestinal and neurologic adverse effects and proarrhythmic risk.
How serious is the interaction between Mexiletine and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, dizziness, nausea and arrhythmia and reduce the mexiletine dose if they occur. Check plasma levels when available.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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