Drug interactions
Midazolam + Paliperidone
Severity: Moderate
Midazolam and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can add to the sedative effect of midazolam and may contribute to orthostatic hypotension and dizziness. Impairment of alertness may be greater than with either drug alone.
What this interaction means in plain words
Midazolam and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic blockade.
What to do
Use the lowest effective midazolam dose and monitor sedation and blood pressure; counsel patients about driving and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Midazolam with Paliperidone?
MediHelp rates the interaction as moderate. Midazolam and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can add to the sedative effect of midazolam and may contribute to orthostatic hypotension and dizziness. Impairment of alertness may be greater than with either drug alone.
How serious is the interaction between Midazolam and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation and blood pressure; counsel patients about driving and falls.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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