Drug interactions
Midazolam + Perphenazine
Severity: Moderate
Midazolam and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine adds to the sedating and hypotensive effects of midazolam, increasing the risk of excessive drowsiness and respiratory depression.
What this interaction means in plain words
Midazolam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from dopamine, histamine and alpha-adrenergic antagonism combined with GABA-A potentiation.
What to do
Start with lower midazolam doses and monitor sedation, blood pressure and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Midazolam with Perphenazine?
MediHelp rates the interaction as moderate. Midazolam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine adds to the sedating and hypotensive effects of midazolam, increasing the risk of excessive drowsiness and respiratory depression.
How serious is the interaction between Midazolam and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower midazolam doses and monitor sedation, blood pressure and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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