Drug interactions
Midazolam + Ritlecitinib
Severity: Moderate
Midazolam and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP3A4 and raises exposure to sensitive substrates such as midazolam. This may cause prolonged sedation and respiratory depression.
What this interaction means in plain words
Midazolam and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Ritlecitinib belongs to Oncology.
Why it happens
Ritlecitinib inhibits CYP3A4, decreasing midazolam clearance.
What to do
Monitor for increased or prolonged sedation and reduce the midazolam dose as required, particularly with oral dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Midazolam with Ritlecitinib?
MediHelp rates the interaction as moderate. Midazolam and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP3A4 and raises exposure to sensitive substrates such as midazolam. This may cause prolonged sedation and respiratory depression.
How serious is the interaction between Midazolam and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased or prolonged sedation and reduce the midazolam dose as required, particularly with oral dosing.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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