Drug interactions
Midazolam + Talquetamab
Severity: Moderate
Midazolam and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release that may transiently suppress CYP enzymes, potentially raising midazolam exposure. This is most likely during step-up dosing and around cytokine release syndrome episodes, and may cause excessive sedation.
What this interaction means in plain words
Midazolam and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity decreases midazolam clearance.
What to do
Monitor for excess sedation and respiratory depression during step-up dosing and CRS, and reduce the midazolam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Midazolam with Talquetamab?
MediHelp rates the interaction as moderate. Midazolam and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release that may transiently suppress CYP enzymes, potentially raising midazolam exposure. This is most likely during step-up dosing and around cytokine release syndrome episodes, and may cause excessive sedation.
How serious is the interaction between Midazolam and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression during step-up dosing and CRS, and reduce the midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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