Drug interactions
Midazolam + Trofinetide
Severity: Minor
Midazolam and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. The result may be somewhat more or longer sedation, mainly with oral midazolam.
What this interaction means in plain words
Midazolam and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Trofinetide belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by trofinetide reduces midazolam clearance.
What to do
Monitor sedation after midazolam doses and reduce the dose if effect is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Midazolam with Trofinetide?
MediHelp rates the interaction as minor. Midazolam and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. The result may be somewhat more or longer sedation, mainly with oral midazolam.
How serious is the interaction between Midazolam and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after midazolam doses and reduce the dose if effect is excessive.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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