Drug interactions
Midazolam + Ziconotide
Severity: Moderate
Midazolam and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, and ziconotide can cause sedation, confusion and impaired consciousness. Combined use may increase the risk of excessive sedation and cognitive impairment.
What this interaction means in plain words
Midazolam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor level of consciousness and cognition, and reduce the midazolam dose if sedation increases; consider stopping or lowering ziconotide if mental status worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Midazolam with Ziconotide?
MediHelp rates the interaction as moderate. Midazolam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, and ziconotide can cause sedation, confusion and impaired consciousness. Combined use may increase the risk of excessive sedation and cognitive impairment.
How serious is the interaction between Midazolam and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and cognition, and reduce the midazolam dose if sedation increases; consider stopping or lowering ziconotide if mental status worsens.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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