Drug interactions
Midodrine + Procarbazine
Severity: Major
Midodrine and Procarbazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity and can potentiate sympathomimetic agents. Combined with midodrine, an alpha-1 agonist, this may cause severe hypertension, including a hypertensive crisis.
What this interaction means in plain words
Midodrine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midodrine belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine augments adrenergic pressor effects, adding to midodrine's alpha-1 mediated vasoconstriction.
What to do
Avoid the combination where possible. If used together, monitor blood pressure closely, including supine readings, and reduce or stop midodrine for elevated values.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Midodrine with Procarbazine?
MediHelp rates the interaction as major. Midodrine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has weak monoamine oxidase inhibiting activity and can potentiate sympathomimetic agents. Combined with midodrine, an alpha-1 agonist, this may cause severe hypertension, including a hypertensive crisis.
How serious is the interaction between Midodrine and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor blood pressure closely, including supine readings, and reduce or stop midodrine for elevated values.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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