Drug interactions
Midodrine + Quetiapine
Severity: Moderate
Midodrine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which directly opposes the vasopressor action of midodrine. The effectiveness of midodrine may be reduced, and sedation effects are unpredictable.
What this interaction means in plain words
Midodrine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between alpha-1 blockade by quetiapine and alpha-1 agonism by midodrine.
What to do
Monitor seated and standing blood pressure and symptoms of orthostasis. Adjust midodrine dose or consider an antipsychotic with less alpha-blockade if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midodrine and Quetiapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Quetiapine?
MediHelp rates the interaction as moderate. Midodrine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which directly opposes the vasopressor action of midodrine. The effectiveness of midodrine may be reduced, and sedation effects are unpredictable.
How serious is the interaction between Midodrine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seated and standing blood pressure and symptoms of orthostasis. Adjust midodrine dose or consider an antipsychotic with less alpha-blockade if hypotension persists.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
