Drug interactions
Midodrine + Quinidine
Severity: Minor
Midodrine and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of midodrine, desglymidodrine, is secreted by renal cationic transport. Quinidine may compete for this pathway, which could slightly increase midodrine effects such as supine hypertension, bradycardia or piloerection. The clinical impact is probably limited.
What this interaction means in plain words
Midodrine and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midodrine belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular cationic secretion may reduce clearance of desglymidodrine.
What to do
Monitor supine and standing blood pressure and heart rate. Reduce the midodrine dose if supine hypertension or bradycardia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Quinidine?
MediHelp rates the interaction as minor. Midodrine and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of midodrine, desglymidodrine, is secreted by renal cationic transport. Quinidine may compete for this pathway, which could slightly increase midodrine effects such as supine hypertension, bradycardia or piloerection. The clinical impact is probably limited.
How serious is the interaction between Midodrine and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and heart rate. Reduce the midodrine dose if supine hypertension or bradycardia develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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