Drug interactions
Midostaurin + Nicardipine
Severity: Moderate
Midostaurin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin is a CYP3A4 substrate, and nicardipine may modestly increase its exposure. This may heighten nausea, vomiting, myelosuppression and QT effects.
What this interaction means in plain words
Midostaurin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midostaurin belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing midostaurin clearance.
What to do
Monitor for GI toxicity, blood counts and ECG changes, especially in the first week. Consider an alternative antihypertensive with little CYP3A4 effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Nicardipine?
MediHelp rates the interaction as moderate. Midostaurin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin is a CYP3A4 substrate, and nicardipine may modestly increase its exposure. This may heighten nausea, vomiting, myelosuppression and QT effects.
How serious is the interaction between Midostaurin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI toxicity, blood counts and ECG changes, especially in the first week. Consider an alternative antihypertensive with little CYP3A4 effect.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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