Drug interactions
Midostaurin + Primaquine
Severity: Major
Midostaurin and Primaquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and primaquine may add to this effect. Together they may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Midostaurin and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible. If coadministered, monitor the ECG and electrolytes at baseline and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Primaquine?
MediHelp rates the interaction as major. Midostaurin and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin has been associated with QT prolongation, and primaquine may add to this effect. Together they may increase the risk of ventricular arrhythmia.
How serious is the interaction between Midostaurin and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministered, monitor the ECG and electrolytes at baseline and periodically.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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