Drug interactions
Midostaurin + Rifampicin
Severity: Major
Midostaurin and Rifampicin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin markedly reduces midostaurin and active metabolite concentrations, which may compromise efficacy in AML.
What this interaction means in plain words
Midostaurin and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
Strong CYP3A4 induction accelerates midostaurin metabolism.
What to do
Avoid; use an alternative antituberculous agent. If unavoidable, monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midostaurin
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Midostaurin with Rifampicin?
MediHelp rates the interaction as major. Midostaurin and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly reduces midostaurin and active metabolite concentrations, which may compromise efficacy in AML.
How serious is the interaction between Midostaurin and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an alternative antituberculous agent. If unavoidable, monitor response.
What other medicines interact with Midostaurin?
MediHelp also lists interactions of Midostaurin with, for example, Alfuzosin, Amisulpride, Amobarbital. The full list is on the Midostaurin page.
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