Drug interactions
Midostaurin + Secobarbital
Severity: Major
Midostaurin and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital, a barbiturate, can induce CYP3A4 and lower midostaurin exposure. Midostaurin labeling advises avoiding strong CYP3A inducers because lower drug levels may reduce antileukemic efficacy.
What this interaction means in plain words
Midostaurin and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of hepatic and intestinal CYP3A4 by the barbiturate increases the metabolism of midostaurin.
What to do
Avoid the combination and choose a non-inducing sedative or hypnotic. If it cannot be avoided, monitor the leukemia response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Secobarbital?
MediHelp rates the interaction as major. Midostaurin and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital, a barbiturate, can induce CYP3A4 and lower midostaurin exposure. Midostaurin labeling advises avoiding strong CYP3A inducers because lower drug levels may reduce antileukemic efficacy.
How serious is the interaction between Midostaurin and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative or hypnotic. If it cannot be avoided, monitor the leukemia response closely.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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