Drug interactions
Midostaurin + Sertraline
Severity: Moderate
Midostaurin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval and sertraline has a modest QT effect, so combined use may raise the risk of arrhythmia. The risk increases with electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Midostaurin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midostaurin belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during therapy. Consider an alternative antidepressant with less QT effect if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Sertraline?
MediHelp rates the interaction as moderate. Midostaurin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin can prolong the QT interval and sertraline has a modest QT effect, so combined use may raise the risk of arrhythmia. The risk increases with electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Midostaurin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during therapy. Consider an alternative antidepressant with less QT effect if the QTc lengthens.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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