Drug interactions
Mifepristone + Modafinil
Severity: Minor
Mifepristone and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may modestly raise modafinil exposure, since CYP3A4 is one route of modafinil metabolism. The clinical effect is likely small and shows up as more adverse effects such as headache, anxiety or insomnia.
What this interaction means in plain words
Mifepristone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Modafinil belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated modafinil metabolism by mifepristone.
What to do
No routine dose change is needed. Watch for increased modafinil adverse effects such as insomnia, anxiety and headache, and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Modafinil?
MediHelp rates the interaction as minor. Mifepristone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may modestly raise modafinil exposure, since CYP3A4 is one route of modafinil metabolism. The clinical effect is likely small and shows up as more adverse effects such as headache, anxiety or insomnia.
How serious is the interaction between Mifepristone and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased modafinil adverse effects such as insomnia, anxiety and headache, and reduce the dose if they occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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