Drug interactions
Mifepristone + Mometasone
Severity: Minor
Mifepristone and Mometasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone antagonizes glucocorticoid receptors and may reduce corticosteroid effect. Topical mometasone has minimal systemic exposure, so a clinically meaningful interaction is unlikely.
What this interaction means in plain words
Mifepristone and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Mometasone belongs to Respiratory.
Why it happens
Glucocorticoid receptor antagonism by mifepristone.
What to do
No change needed for short-term topical use. With extensive or prolonged use, watch for reduced steroid response or adrenal insufficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Mometasone?
MediHelp rates the interaction as minor. Mifepristone and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone antagonizes glucocorticoid receptors and may reduce corticosteroid effect. Topical mometasone has minimal systemic exposure, so a clinically meaningful interaction is unlikely.
How serious is the interaction between Mifepristone and Mometasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change needed for short-term topical use. With extensive or prolonged use, watch for reduced steroid response or adrenal insufficiency.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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