Drug interactions
Mifepristone + Ozanimod
Severity: Moderate
Mifepristone and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause bradycardia and conduction effects, and mifepristone prolongs the QT interval. Combined use may increase proarrhythmic risk, particularly torsades de pointes.
What this interaction means in plain words
Mifepristone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiac effects: ozanimod-induced bradycardia combined with mifepristone QT prolongation.
What to do
Obtain a baseline ECG before starting ozanimod and monitor heart rate and ECG during therapy. Correct electrolyte abnormalities and consider specialist advice before starting ozanimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mifepristone with Ozanimod?
MediHelp rates the interaction as moderate. Mifepristone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause bradycardia and conduction effects, and mifepristone prolongs the QT interval. Combined use may increase proarrhythmic risk, particularly torsades de pointes.
How serious is the interaction between Mifepristone and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and monitor heart rate and ECG during therapy. Correct electrolyte abnormalities and consider specialist advice before starting ozanimod.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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