Drug interactions
Mifepristone + Panobinostat
Severity: Major
Mifepristone and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and mifepristone may raise panobinostat levels through CYP3A4 inhibition. The combination increases the risk of serious ventricular arrhythmias including torsade de pointes.
What this interaction means in plain words
Mifepristone and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Panobinostat belongs to Oncology.
Why it happens
Additive QT prolongation and CYP3A4 inhibition by mifepristone raising panobinostat exposure.
What to do
Avoid the combination. If it must be used, monitor ECG, potassium and magnesium closely and reduce the panobinostat dose according to labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Mifepristone with Panobinostat?
MediHelp rates the interaction as major. Mifepristone and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and mifepristone may raise panobinostat levels through CYP3A4 inhibition. The combination increases the risk of serious ventricular arrhythmias including torsade de pointes.
How serious is the interaction between Mifepristone and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it must be used, monitor ECG, potassium and magnesium closely and reduce the panobinostat dose according to labeling.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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