Drug interactions
Mifepristone + Polatuzumab vedotin
Severity: Moderate
Mifepristone and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload MMAE released from polatuzumab vedotin is a CYP3A4 substrate. Mifepristone, as a CYP3A4 inhibitor, may raise unconjugated MMAE exposure and increase toxicities such as neutropenia and peripheral neuropathy.
What this interaction means in plain words
Mifepristone and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Polatuzumab vedotin belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing clearance of MMAE.
What to do
Monitor blood counts and neuropathy symptoms more closely during polatuzumab therapy. Consider an alternative to mifepristone if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Mifepristone with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Mifepristone and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE released from polatuzumab vedotin is a CYP3A4 substrate. Mifepristone, as a CYP3A4 inhibitor, may raise unconjugated MMAE exposure and increase toxicities such as neutropenia and peripheral neuropathy.
How serious is the interaction between Mifepristone and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms more closely during polatuzumab therapy. Consider an alternative to mifepristone if feasible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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