Drug interactions
Mifepristone + Repotrectinib
Severity: Major
Mifepristone and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is cleared mainly by CYP3A4, and mifepristone inhibits this enzyme strongly. Co-use is expected to increase repotrectinib exposure and the risk of CNS effects such as dizziness and ataxia, as well as hepatotoxicity and other toxicity.
What this interaction means in plain words
Mifepristone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing repotrectinib clearance.
What to do
Avoid concomitant use. Because mifepristone has a long half-life, allow adequate washout before starting repotrectinib and monitor closely if exposure overlaps.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Mifepristone with Repotrectinib?
MediHelp rates the interaction as major. Mifepristone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is cleared mainly by CYP3A4, and mifepristone inhibits this enzyme strongly. Co-use is expected to increase repotrectinib exposure and the risk of CNS effects such as dizziness and ataxia, as well as hepatotoxicity and other toxicity.
How serious is the interaction between Mifepristone and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Because mifepristone has a long half-life, allow adequate washout before starting repotrectinib and monitor closely if exposure overlaps.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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