Drug interactions
Mifepristone + Rucaparib
Severity: Minor
Mifepristone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and may raise mifepristone concentrations. Mifepristone has dose-related adverse effects, so increased exposure may be relevant, though the clinical impact is modest.
What this interaction means in plain words
Mifepristone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing mifepristone clearance.
What to do
No routine adjustment is needed; monitor for mifepristone adverse effects and adjust the dose if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Mifepristone with Rucaparib?
MediHelp rates the interaction as minor. Mifepristone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and may raise mifepristone concentrations. Mifepristone has dose-related adverse effects, so increased exposure may be relevant, though the clinical impact is modest.
How serious is the interaction between Mifepristone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for mifepristone adverse effects and adjust the dose if clinically indicated.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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