Drug interactions
Mifepristone + Sevoflurane
Severity: Moderate
Mifepristone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, can prolong the QT interval. Sevoflurane adds to repolarization delay, so the combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Mifepristone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline QTc and correct hypokalemia, which is common in Cushing syndrome. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Sevoflurane?
MediHelp rates the interaction as moderate. Mifepristone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone, particularly at the higher doses used for Cushing syndrome, can prolong the QT interval. Sevoflurane adds to repolarization delay, so the combination may raise the risk of torsades de pointes.
How serious is the interaction between Mifepristone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct hypokalemia, which is common in Cushing syndrome. Monitor the ECG during anesthesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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