Drug interactions
Mifepristone + Stiripentol
Severity: Moderate
Mifepristone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is metabolized by several CYP enzymes including CYP3A4, so a CYP3A4 inhibitor may modestly increase its exposure. The clinical consequence is likely greater sedation, somnolence and reduced appetite.
What this interaction means in plain words
Mifepristone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4, a minor contributor to stiripentol clearance.
What to do
Monitor for sedation, ataxia and decreased appetite, and reduce the stiripentol dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Mifepristone with Stiripentol?
MediHelp rates the interaction as moderate. Mifepristone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is metabolized by several CYP enzymes including CYP3A4, so a CYP3A4 inhibitor may modestly increase its exposure. The clinical consequence is likely greater sedation, somnolence and reduced appetite.
How serious is the interaction between Mifepristone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and decreased appetite, and reduce the stiripentol dose if adverse effects occur.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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