Drug interactions
Mifepristone + Temsirolimus
Severity: Major
Mifepristone and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase exposure to temsirolimus and its active metabolite sirolimus by inhibiting CYP3A4. This could increase myelosuppression, metabolic effects, mucositis and pneumonitis.
What this interaction means in plain words
Mifepristone and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
CYP3A4 inhibition by mifepristone reduces the metabolism of temsirolimus and sirolimus.
What to do
Avoid if possible; otherwise reduce the temsirolimus dose and monitor for toxicity, restoring the dose about a week after mifepristone is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Mifepristone with Temsirolimus?
MediHelp rates the interaction as major. Mifepristone and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone may increase exposure to temsirolimus and its active metabolite sirolimus by inhibiting CYP3A4. This could increase myelosuppression, metabolic effects, mucositis and pneumonitis.
How serious is the interaction between Mifepristone and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the temsirolimus dose and monitor for toxicity, restoring the dose about a week after mifepristone is stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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