Drug interactions
Mifepristone + Tramadol
Severity: Moderate
Mifepristone and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise tramadol concentrations, particularly with prolonged daily dosing such as in Cushing's syndrome. Higher exposure may increase the risk of sedation, seizures and serotonin syndrome. A single abortion dose is less likely to matter.
What this interaction means in plain words
Mifepristone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tramadol belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated tramadol metabolism, increasing tramadol concentrations.
What to do
Monitor for opioid adverse effects, seizures and serotonin toxicity and consider a lower tramadol dose during chronic mifepristone therapy. Reassess after mifepristone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tramadol?
MediHelp rates the interaction as moderate. Mifepristone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise tramadol concentrations, particularly with prolonged daily dosing such as in Cushing's syndrome. Higher exposure may increase the risk of sedation, seizures and serotonin syndrome. A single abortion dose is less likely to matter.
How serious is the interaction between Mifepristone and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid adverse effects, seizures and serotonin toxicity and consider a lower tramadol dose during chronic mifepristone therapy. Reassess after mifepristone is stopped.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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