Drug interactions
Mifepristone + Upadacitinib
Severity: Moderate
Mifepristone and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib is metabolized mainly by CYP3A4, and strong inhibitors raise its exposure. Mifepristone inhibits CYP3A4, which may increase the risk of infection, cytopenias and other dose-related adverse effects.
What this interaction means in plain words
Mifepristone and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Upadacitinib belongs to Musculoskeletal.
Why it happens
Mifepristone inhibits CYP3A4, reducing upadacitinib clearance.
What to do
Follow upadacitinib labeling for strong CYP3A4 inhibitors, using the lower dose where specified. Monitor for infections and blood count abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Mifepristone with Upadacitinib?
MediHelp rates the interaction as moderate. Mifepristone and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Upadacitinib is metabolized mainly by CYP3A4, and strong inhibitors raise its exposure. Mifepristone inhibits CYP3A4, which may increase the risk of infection, cytopenias and other dose-related adverse effects.
How serious is the interaction between Mifepristone and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow upadacitinib labeling for strong CYP3A4 inhibitors, using the lower dose where specified. Monitor for infections and blood count abnormalities.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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