Drug interactions
Milnacipran + Pregabalin
Severity: Moderate
Milnacipran and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes dose-related sedation and dizziness, and may add to the CNS effects of milnacipran. Combined use can increase drowsiness, impaired concentration and fall risk, particularly in older or frail patients.
What this interaction means in plain words
Milnacipran and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Milnacipran belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system effects; both drugs can impair psychomotor function.
What to do
Start pregabalin at a low dose and titrate slowly, monitoring for sedation, dizziness and cognitive impairment. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Milnacipran with Pregabalin?
MediHelp rates the interaction as moderate. Milnacipran and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin causes dose-related sedation and dizziness, and may add to the CNS effects of milnacipran. Combined use can increase drowsiness, impaired concentration and fall risk, particularly in older or frail patients.
How serious is the interaction between Milnacipran and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pregabalin at a low dose and titrate slowly, monitoring for sedation, dizziness and cognitive impairment. Counsel patients about driving and alcohol.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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