Drug interactions
Mirabegron + Perphenazine
Severity: Moderate
Mirabegron and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is cleared mainly by CYP2D6, so mirabegron may raise its levels. This can increase extrapyramidal symptoms, sedation and QT effects.
What this interaction means in plain words
Mirabegron and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Perphenazine belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, decreasing perphenazine metabolism.
What to do
Monitor for extrapyramidal symptoms and sedation, and reduce the perphenazine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Mirabegron with Perphenazine?
MediHelp rates the interaction as moderate. Mirabegron and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is cleared mainly by CYP2D6, so mirabegron may raise its levels. This can increase extrapyramidal symptoms, sedation and QT effects.
How serious is the interaction between Mirabegron and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, and reduce the perphenazine dose if they occur.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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