Drug interactions
Mirabegron + Promethazine
Severity: Minor
Mirabegron and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and promethazine is partly metabolized by CYP2D6. Promethazine levels may rise, with more sedation and anticholinergic effects. The clinical impact is usually modest.
What this interaction means in plain words
Mirabegron and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Promethazine belongs to Respiratory.
Why it happens
Mirabegron inhibits CYP2D6, reducing promethazine metabolism.
What to do
No routine dose change is needed; watch for increased drowsiness or anticholinergic effects and reduce promethazine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Promethazine?
MediHelp rates the interaction as minor. Mirabegron and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirabegron is a moderate CYP2D6 inhibitor and promethazine is partly metabolized by CYP2D6. Promethazine levels may rise, with more sedation and anticholinergic effects. The clinical impact is usually modest.
How serious is the interaction between Mirabegron and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased drowsiness or anticholinergic effects and reduce promethazine dose if they occur.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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