Drug interactions
Mirabegron + Solifenacin
Severity: Minor
Mirabegron and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and has little effect on CYP3A4, so the effect on solifenacin exposure is minimal. The two are used together therapeutically, but combination can increase heart rate, blood pressure and the risk of urinary retention.
What this interaction means in plain words
Mirabegron and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Solifenacin belongs to Genitourinary.
Why it happens
Largely pharmacodynamic: antimuscarinic bladder effect plus beta-3 agonism; no meaningful pharmacokinetic interaction.
What to do
No dose adjustment is required; monitor blood pressure and watch for urinary retention, particularly in men with outlet obstruction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Solifenacin?
MediHelp rates the interaction as minor. Mirabegron and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirabegron is a moderate CYP2D6 inhibitor and has little effect on CYP3A4, so the effect on solifenacin exposure is minimal. The two are used together therapeutically, but combination can increase heart rate, blood pressure and the risk of urinary retention.
How serious is the interaction between Mirabegron and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor blood pressure and watch for urinary retention, particularly in men with outlet obstruction.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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