Drug interactions
Mirtazapine + Nalbuphine
Severity: Moderate
Mirtazapine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and together they can increase drowsiness, dizziness and impaired psychomotor performance. The effect is most noticeable at initiation or after a dose increase.
What this interaction means in plain words
Mirtazapine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from opioid receptor activity and mirtazapine's histamine H1 antagonism.
What to do
Use the lowest effective doses and counsel the patient about driving and alcohol. Reduce the dose if daytime sedation or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Nalbuphine?
MediHelp rates the interaction as moderate. Mirtazapine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and together they can increase drowsiness, dizziness and impaired psychomotor performance. The effect is most noticeable at initiation or after a dose increase.
How serious is the interaction between Mirtazapine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel the patient about driving and alcohol. Reduce the dose if daytime sedation or confusion develops.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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