Drug interactions
Mirtazapine + Orphenadrin
Severity: Moderate
Mirtazapine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is strongly sedating through histamine blockade, and orphenadrine adds central depression plus anticholinergic effects. This can lead to excessive drowsiness, confusion and impaired psychomotor function.
What this interaction means in plain words
Mirtazapine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive sedation from central nervous system depression and antihistaminic effects, plus anticholinergic burden.
What to do
Monitor for oversedation and confusion, especially in older patients, and counsel about driving. Reduce doses if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Orphenadrin?
MediHelp rates the interaction as moderate. Mirtazapine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is strongly sedating through histamine blockade, and orphenadrine adds central depression plus anticholinergic effects. This can lead to excessive drowsiness, confusion and impaired psychomotor function.
How serious is the interaction between Mirtazapine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion, especially in older patients, and counsel about driving. Reduce doses if daytime impairment occurs.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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