Drug interactions
Mirtazapine + Primaquine
Severity: Moderate
Mirtazapine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine and mirtazapine each have some potential to prolong the QT interval. Together they may modestly raise the risk of arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Mirtazapine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation; the effect of each drug is modest.
What to do
Check a baseline ECG in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs. Correct potassium and magnesium abnormalities and reassess if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mirtazapine and Primaquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Primaquine?
MediHelp rates the interaction as moderate. Mirtazapine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine and mirtazapine each have some potential to prolong the QT interval. Together they may modestly raise the risk of arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Mirtazapine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs. Correct potassium and magnesium abnormalities and reassess if palpitations or syncope occur.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
