Drug interactions
Mirtazapine + Quinidine
Severity: Moderate
Mirtazapine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been associated with QT prolongation, particularly in overdose, and may add to quinidine's effect. The combination increases the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Mirtazapine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and monitor QTc, and keep potassium and magnesium normal. Consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Quinidine?
MediHelp rates the interaction as moderate. Mirtazapine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has been associated with QT prolongation, particularly in overdose, and may add to quinidine's effect. The combination increases the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Mirtazapine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc, and keep potassium and magnesium normal. Consider an alternative antidepressant in high-risk patients.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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