Drug interactions
Mirtazapine + Terbinafine
Severity: Minor
Mirtazapine and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is metabolized by CYP2D6, CYP3A4 and CYP1A2, so CYP2D6 inhibition by terbinafine would have a limited effect. A small rise in levels could slightly increase sedation or other adverse effects.
What this interaction means in plain words
Mirtazapine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirtazapine belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6, one of several pathways metabolizing mirtazapine.
What to do
No routine dose change is needed. Watch for excess sedation or dizziness and reduce the mirtazapine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mirtazapine and Terbinafine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Terbinafine?
MediHelp rates the interaction as minor. Mirtazapine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine is metabolized by CYP2D6, CYP3A4 and CYP1A2, so CYP2D6 inhibition by terbinafine would have a limited effect. A small rise in levels could slightly increase sedation or other adverse effects.
How serious is the interaction between Mirtazapine and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for excess sedation or dizziness and reduce the mirtazapine dose if they occur.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
