Drug interactions
Mirtazapine + Tranylcypromine
Severity: Contraindicated
Mirtazapine and Tranylcypromine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining mirtazapine with a nonselective MAO inhibitor can cause serotonin syndrome and, with tranylcypromine, hypertensive reactions. Mirtazapine labeling contraindicates use with MAOIs or within 14 days of stopping one.
What this interaction means in plain words
Mirtazapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition raises monoamine levels, which adds to the serotonergic and noradrenergic effects of mirtazapine.
What to do
Do not coadminister. Allow at least 14 days between stopping either drug and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Mirtazapine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Mirtazapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining mirtazapine with a nonselective MAO inhibitor can cause serotonin syndrome and, with tranylcypromine, hypertensive reactions. Mirtazapine labeling contraindicates use with MAOIs or within 14 days of stopping one.
How serious is the interaction between Mirtazapine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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