Drug interactions
Mitomycin + Ofatumumab sc
Severity: Moderate
Mitomycin and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin is myelosuppressive and immunosuppressive, and ofatumumab depletes B cells. Together they may increase the risk of infection, including serious or opportunistic infections. Ofatumumab SC is used in multiple sclerosis, where chemotherapy is uncommon.
What this interaction means in plain words
Mitomycin and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic bone marrow suppression.
What to do
Monitor blood counts and watch for infection during combined therapy. Consider the duration of immunosuppression from prior therapy before starting ofatumumab, and avoid live vaccines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Ofatumumab sc?
MediHelp rates the interaction as moderate. Mitomycin and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin is myelosuppressive and immunosuppressive, and ofatumumab depletes B cells. Together they may increase the risk of infection, including serious or opportunistic infections. Ofatumumab SC is used in multiple sclerosis, where chemotherapy is uncommon.
How serious is the interaction between Mitomycin and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection during combined therapy. Consider the duration of immunosuppression from prior therapy before starting ofatumumab, and avoid live vaccines.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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