Drug interactions
Mitomycin + Ponatinib
Severity: Moderate
Mitomycin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates such as mitomycin. Both agents can cause myelosuppression, so toxicity may be additive. Clinical data on this pair are lacking.
What this interaction means in plain words
Mitomycin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitomycin belongs to Oncology; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-gp efflux, potentially raising mitomycin levels; additive myelosuppression is also possible.
What to do
Monitor complete blood counts regularly and reduce the mitomycin dose if marked cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Mitomycin with Ponatinib?
MediHelp rates the interaction as moderate. Mitomycin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates such as mitomycin. Both agents can cause myelosuppression, so toxicity may be additive. Clinical data on this pair are lacking.
How serious is the interaction between Mitomycin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce the mitomycin dose if marked cytopenias develop.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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