Drug interactions
Mitomycin + Tenofovir df
Severity: Moderate
Mitomycin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin can cause nephrotoxicity, including hemolytic uremic syndrome, and tenofovir DF is also associated with renal tubular toxicity. Combined use may worsen renal function and raise tenofovir exposure when renal clearance falls.
What this interaction means in plain words
Mitomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity with reduced renal elimination of tenofovir as kidney function declines.
What to do
Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the tenofovir dosing interval to renal function or switch to tenofovir alafenamide if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Tenofovir df?
MediHelp rates the interaction as moderate. Mitomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin can cause nephrotoxicity, including hemolytic uremic syndrome, and tenofovir DF is also associated with renal tubular toxicity. Combined use may worsen renal function and raise tenofovir exposure when renal clearance falls.
How serious is the interaction between Mitomycin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the tenofovir dosing interval to renal function or switch to tenofovir alafenamide if renal function declines.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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