Drug interactions
Mitomycin + Tenofovir disoproxil
Severity: Moderate
Mitomycin and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin can cause renal toxicity, including hemolytic uremic syndrome, and tenofovir may add to tubular injury. Concurrent use may increase the risk of kidney dysfunction, which in turn raises tenofovir exposure.
What this interaction means in plain words
Mitomycin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity with reduced renal clearance of tenofovir.
What to do
Monitor creatinine, phosphate and blood counts before and during mitomycin treatment. Adjust tenofovir for renal function or change to a less renally toxic agent if function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mitomycin and Tenofovir disoproxil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Mitomycin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin can cause renal toxicity, including hemolytic uremic syndrome, and tenofovir may add to tubular injury. Concurrent use may increase the risk of kidney dysfunction, which in turn raises tenofovir exposure.
How serious is the interaction between Mitomycin and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, phosphate and blood counts before and during mitomycin treatment. Adjust tenofovir for renal function or change to a less renally toxic agent if function declines.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
