Drug interactions
Mitomycin + Vincristine liposomal
Severity: Major
Mitomycin and Vincristine liposomal: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinca alkaloids given with or shortly after mitomycin have been associated with acute bronchospasm and severe shortness of breath. The reaction can be serious and may require treatment with bronchodilators or corticosteroids.
What this interaction means in plain words
Mitomycin and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mechanism is not established; a pulmonary toxicity reaction involving both agents is suspected.
What to do
Avoid combining where possible, and monitor respiratory status closely if used together. Stop therapy and treat bronchospasm if dyspnea develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Vincristine liposomal?
MediHelp rates the interaction as major. Mitomycin and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinca alkaloids given with or shortly after mitomycin have been associated with acute bronchospasm and severe shortness of breath. The reaction can be serious and may require treatment with bronchodilators or corticosteroids.
How serious is the interaction between Mitomycin and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and monitor respiratory status closely if used together. Stop therapy and treat bronchospasm if dyspnea develops.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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