Drug interactions
Mitotane + Modafinil
Severity: Moderate
Mitotane and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially lower modafinil concentrations, reducing its wakefulness effect. The inducing effect may persist for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by mitotane increases modafinil clearance.
What to do
Monitor for loss of modafinil efficacy and increase the dose as needed; reassess the dose if mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Modafinil?
MediHelp rates the interaction as moderate. Mitotane and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially lower modafinil concentrations, reducing its wakefulness effect. The inducing effect may persist for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of modafinil efficacy and increase the dose as needed; reassess the dose if mitotane is discontinued.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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