Drug interactions
Mitotane + Palbociclib
Severity: Major
Mitotane and Palbociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer with a long duration of effect and may markedly reduce palbociclib concentrations. This may result in loss of efficacy, and the effect persists after mitotane is stopped.
What this interaction means in plain words
Mitotane and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitotane belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing palbociclib clearance.
What to do
Avoid the combination if possible. If used, monitor for reduced efficacy, remembering that induction persists for weeks after mitotane discontinuation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Palbociclib
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Palbociclib?
MediHelp rates the interaction as major. Mitotane and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer with a long duration of effect and may markedly reduce palbociclib concentrations. This may result in loss of efficacy, and the effect persists after mitotane is stopped.
How serious is the interaction between Mitotane and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor for reduced efficacy, remembering that induction persists for weeks after mitotane discontinuation.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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