Drug interactions
Mitotane + Ropivacaine
Severity: Minor
Mitotane and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and could lower ropivacaine concentrations. Because CYP1A2 is the main pathway for ropivacaine, any loss of effect is likely small.
What this interaction means in plain words
Mitotane and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitotane belongs to Oncology; Ropivacaine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by mitotane increasing ropivacaine clearance.
What to do
No routine dose change is needed. Assess adequacy of anesthesia or analgesia and adjust dosing if the block is shorter than expected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Ropivacaine?
MediHelp rates the interaction as minor. Mitotane and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitotane is a strong CYP3A4 inducer and could lower ropivacaine concentrations. Because CYP1A2 is the main pathway for ropivacaine, any loss of effect is likely small.
How serious is the interaction between Mitotane and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Assess adequacy of anesthesia or analgesia and adjust dosing if the block is shorter than expected.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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