Drug interactions
Mitoxantrone + Momelotinib
Severity: Moderate
Mitoxantrone and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits the efflux transporter BCRP, which helps clear mitoxantrone from the body. Higher mitoxantrone exposure may increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Mitoxantrone and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Momelotinib belongs to Oncology.
Why it happens
Momelotinib inhibits BCRP-mediated efflux of mitoxantrone, raising its systemic exposure.
What to do
Monitor blood counts and cardiac function more closely during co-administration. Consider reducing the mitoxantrone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Mitoxantrone with Momelotinib?
MediHelp rates the interaction as moderate. Mitoxantrone and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits the efflux transporter BCRP, which helps clear mitoxantrone from the body. Higher mitoxantrone exposure may increase myelosuppression and cardiotoxicity.
How serious is the interaction between Mitoxantrone and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function more closely during co-administration. Consider reducing the mitoxantrone dose if toxicity develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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